People - Michael H. Buonocore

Michael H. Buonocore, M.D., Ph.D.
Technical Director, UC Davis Imaging Research Center
Professor of Radiology
Health System obituary

Education
B.S. in Chemistry and Physics, 1977, Syracuse University, Syracuse, NY
M.S. in Electrical Engineering (Information Systems), 1981, Stanford University
Ph.D. in Electrical Engineering (Information Systems), 1983, Stanford University
M.D. (Medicine), 1983, Stanford University

Research Interests
Professor Buonocore explores and develops new applications of magnetic resonance imaging (MRI) to challenging problems in clinical medicine, biomedical engineering, and general industry. His research emphasizes refinement of the technology necessary for these new applications. Currently, he has several research programs using magnetic resonance imaging (MRI) for non-invasive measurement of physiological processes in the living human. These include
(1) measurement and visualization of blood flow in the heart and major vessels,
(2) measurement of neural activation in the cerebral cortex during cognitive and sensorimotor tasks,
(3) measurement of kidney filtration parameters, and
(4) measurement of tissue perfusion in breast tumors.
These programs are carried out with faculty in several departments on the UC Davis campus. Professor Buonocore is mainly involved in developing specialized hardware and software for data acquisition and analysis. For example, the software program BrainMRI has been developed for analysis and visualization of neural activation, and the software program MRIView has been developed for analysis and visualization of blood flow patterns. New MRI pulse sequences and analysis software is currently being developed for breast tissue perfusion measurement and assessment of kidney function.

Representative Publications

Buonocore MH, Katzberg RW (2005). Estimation of extraction fraction (EF) and glomerular filtration rate (GFR) using MRI: considerations derived from a new Gd-chelate biodistribution model simulation. IEEE Trans Med Imaging, 24(5):651-66.

Hugo G. Bogren, Michael H. Buonocore, and Richard J. Valente (2004). Four-dimensional magnetic resonance velocity mapping of blood flow patterns in the aorta in patients with atherosclerotic coronary artery disease compared to age-matched normal subjects. Journal of Magnetic Resonance Imaging, 19:417-427. pdf

David C. Zhu and Michael H. Buonocore (2003). Breast tissue differentiation using arterial spin tagging. Magnetic Resonance in Medicine, 50:966-975. pdf

Hildebrand, LB and Buonocore MH (2002). Fully refocused gradient recalled echo (FRGRE): factors affecting flow and motion sensitivity in cardiac MRI. Journal of Cardiovascular Magnetic Resonance, 4(2):211-22.

Buonocore, M.H. and Zhu, D. (2001). Image-based ghost correction for interleaved EPI. Magnetic Resonance in Medicine, 45(1):96-108. pdf

Schumann, CM, Buonocore, MH, and Amaral, DG. (2001). Magnetic resonance imaging of the post-mortem autistic brain. Journal of Autism and Developmental Disorders, 31(6):561-8. pdf

Truscott, KJ and Buonocore, MH (2001). Simulation of tagged MR images with linear tetrahedral solid elements. Journal of Magnetic Resonance Imaging, 14(3):336-40. pdf

Buonocore, MH and Zhu, DC (1999). High spatial resolution EPI using an odd number of interleaves. Magnetic Resonance in Medicine, 41(6):1199-205. pdf

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