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People - Richard Maddock
Richard Maddock, M.D.
Professor of Psychiatry
916-734-3286
Education
1982 - MD - University of California, Davis
1975 - MS - University of California, Davis - Physiology
1970 - BA - University of California, Davis - Psychology
Research Interests
The most general hypothesis that guides research in my laboratory is that emotional disorders (such as anxiety disorders and mood disorders) arise from dysfunction of regulatory mechanisms that normally govern emotional processes. From this perspective, I conduct fMRI, cognitive, and psychophysiological studies of affective processes in patients with these disorders and normal volunteers. Current studies are focused on generating and testing models of the neural systems that underlie the regulation of negative emotional responses. Prior studies of the posterior cingulate cortex have shown this region to be consistently activated during the evaluation of emotionally salient stimuli. Several lines of evidence support our hypothesis that this region plays a role in the interaction between emotional processing and memory. FMRI and behavioral studies in progress aim to further elucidate the interactions between emotion and memory their neural mechanisms.
Patients who experience repeated, spontaneous panic attacks consistently demonstrate an exaggerated lactic acid response in the brain during systemic alkalosis. My laboratory uses magnetic resonance spectroscopy to test competing hypotheses regarding the mechanism of this effect. We have implemented methods for reliably measuring lactate in normal brain and have recently demonstrated exaggerated brain lactate responses during visual stimulation in patients with panic disorder. Current studies aim to determine if this abnormality has a role in the pathogenesis of panic disorder.
Representative Publications
Maddock RJ, Buonocore M.H., Copeland L.E., Richards A.L. (2007). Elevated Brain Lactate Responses to Neural Activation in Panic Disorder: A Dynamic 1H-MRS Study. Molecular Psychiatry, advance online publication 8 January 2008; doi: 10.1038/sj.mp.4002137 pdf
Maddock RJ, Buonocore MH (2007). Measuring Brain Lactate at Rest and during Visual Stimulation: Reply to Sijens and Oudkerk. Psychiatry Research Neuroimaging, 162:175-179, 2008.
Garrett AS, Maddock RJ. Separating subjective emotion from the perception of emotion-inducing stimuli: An fMRI study (2006). NeuroImage, 33:263-74.
Maddock RJ, Buonocore MH, Lavoie SP, Copeland LE, Kile SJ, Richards AL, Ryan JM (2006). Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: A proton magnetic resonance spectroscopy study at 1.5 Tesla. Psychiatry Research: Neuroimaging, 148:47-54. pdf
Bourgeois JA, Maddock RJ, Rogers L, Greco CM, Mangrulkar RS, Saint S (2005). Neurosarcoidosis and delirium. Psychosomatics, 46(2):148-50. pdf
Maddock, R.J., Buonocore, M.H., Kile, S.J., Garrett, A.S. (2003). Brain regions showing increased activation by threat-related words in panic disorder. Neuroreport, 14:325-8. pdf
Maddock, RJ, Garrett, AS and Buonocore MH (2003). Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Human Brain Mapping, 18(1):30-41. pdf
Rita Hargrave, Richard J. Maddock, Valerie Stone (2002). Impaired recognition of facial expressions of emotion in Alzheimer's disease. Journal of Neuropsychiatry and Clinical Neuroscience, 14(1):64-71. pdf
Garrett, A.S., Maddock, R.J. (2001). Time course of the subjective emotional response to aversive pictures: relevance to fMRI studies. Psychiatry Research: Neuroimaging, 108:39-48. pdf
Maddock, RJ, Garrett, AS and Buonocore MH (2001). Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience, 104(3):667-76. pdf
Richard J. Maddock (2001). The lactic acid response to alkalosis in panic disorder: an integrative review. Journal of Neuropsychiatry and Clinical Neurosciences, 13(1):22-34. pdf
Maddock RJ. (1999). The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain. Trends in Neurosciences, 22:310-316. pdf
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