People - Richard Maddock
Richard Maddock, M.D.
Professor of Psychiatry
1982 - MD - University of California, Davis
1975 - MS - University of California, Davis - Physiology
1970 - BA - University of California, Davis - Psychology
The metabolic infrastructure of the brain is inseparable from its information processing activities. The most general hypothesis that guides research in my laboratory is that brain metabolic dysfunction has an important and under-appreciated role in the pathogenesis of psychiatric disorders. Current studies are focused on constraining and testing models in which disturbances of brain metabolism have a causal role in anxiety and mood disorders. Specifically, we are using dynamic magnetic resonance spectroscopy (MRS) to examine the possible role of metabolic disturbances in the neurobiological vulnerability to Panic Disorder. Neural activation leads to characteristic changes in brain lactate, pH, and glutamate metabolism. These changes are abnormal in patients with Panic Disorder. Physical exercise produces a unique brain state that is associated with dramatic increases in non-oxidative metabolism of glucose. This appears to be associated with markedly increased de novo synthesis of brain glutamate and GABA. Understanding these brain metabolic adaptations to physical activity may improve our ability to develop therapeutically effective exercise prescriptions for individual patients with mood and anxiety disorders.
A second focus of research examines disturbances in the metabolic infrastructure of the brain in schizophrenia and related conditions. Neuropathological evidence and current circuit models predict a key role for abnormal brain GABA metabolism in psychotic disorders. Ongoing studies use MRS to test predictions about the involvement of cortical GABA in the pathogenesis and treatment of these conditions. Growing evidence also implicates a role for neuroimmune mechanisms in the pathogenesis of schizophrenia and other neurodevelopmental disorders. My laboratory is using MRS measures of glutathione and other brain metabolites as part of the UC Davis Conte Center studies of neuroimmune mechanisms in psychiatric disorders.
Greenhouse, I., Noah, S., Maddock, R.J., Ivry, R.B. Individual differences in GABA content are reliable but are not uniform across the human cortex. NeuroImage, 139:1-7, 2016. link
Maddock, R.J., Casazza, G.A., Fernandez, D.H., and Maddock, M.I. Acute Modulation of Cortical Glutamate and GABA Content by Physical Activity. Journal of Neuroscience, 36(8):2449-57, 2016. link
Buonocore, M.H. and Maddock, R.J. Magnetic resonance spectroscopy of the brain: A review of physical principles and technical methods. Reviews in the Neurosciences, 26(6):609-32, 2015. link
Maddock, R.J. The problem of spurious correlation between pairs of brain metabolite values measured in the same voxel with MRS. JAMA Psychiatry, 71:338-9, 2014. link
Maddock, R.J., Buonocore, M.H., Miller, A.R., Yoon, J.H., Soosman, S.K., Unruh, A.M. Abnormal activity-dependent brain lactate and glutamate+glutamine responses in panic disorder. Biological Psychiatry, 73(11): 1111-1119, 2013. link
Maddock, R.J., Buonocore, M.H. MR spectroscopic studies of the brain in psychiatric disorders. Current Topics in Behavioral Neuroscience, DOI: 10.1007/7854_2011_197, epublished Feb. 1, 2012. pdf
Maddock, R.J., Casazza, G.A., Buonocore, M.H., Tanase, C. Vigorous exercise increases brain lactate and Glx (glutamate+glutamine): A dynamic 1H-MRS study. NeuroImage, 2011; 57(4): 1324-1330. link
Esquivel, G., Schruers, K.R., Maddock, R.J., Colasanti, A., Griez, E.J. Acids in the brain: A factor in panic? Journal of Psychopharmacology, 24:639-47, 2010. pdf
Yoon, J.H., Maddock, R.J., Rokem, A.S., Silver, M.A., Minzenberg, M.J., Ragland, J.D., Carter, C.S. GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. Journal of Neuroscience, 30:3777-81, 2010. pdf
Maddock, R.J., Frein, S.T. Reduced memory for the spatial and temporal context of unpleasant words. Cognition and Emotion, 23:96-117, 2009. pdf
Maddock, R.J., Buonocore, M.H., Copeland, L.E., Richards, A.L. Elevated brain lactate responses to neural activation in panic disorder: A dynamic 1H-MRS study. Molecular Psychiatry, 14: 537-545, 2009. pdf
Maddock RJ, Buonocore MH. Measuring Brain Lactate at Rest and during Visual Stimulation: Reply to Sijens and Oudkerk. Psychiatry Research Neuroimaging, 162:175-179, 2008.
Garrett AS, Maddock RJ. Separating subjective emotion from the perception of emotion-inducing stimuli: An fMRI study. NeuroImage, 33:263-74, 2006.
Maddock RJ, Buonocore MH, Lavoie SP, Copeland LE, Kile SJ, Richards AL, Ryan JM (2006). Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: A proton magnetic resonance spectroscopy study at 1.5 Tesla. Psychiatry Research: Neuroimaging, 148:47-54. pdf
Maddock, R.J., Buonocore, M.H., Kile, S.J., Garrett, A.S. (2003). Brain regions showing increased activation by threat-related words in panic disorder. Neuroreport, 14:325-8. pdf
Maddock, RJ, Garrett, AS and Buonocore MH (2003). Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Human Brain Mapping, 18(1):30-41. pdf set of 256 matched emotional and neutral words
Rita Hargrave, Richard J. Maddock, Valerie Stone (2002). Impaired recognition of facial expressions of emotion in Alzheimer's disease. Journal of Neuropsychiatry and Clinical Neuroscience, 14(1):64-71. pdf
Garrett, A.S., Maddock, R.J. (2001). Time course of the subjective emotional response to aversive pictures: relevance to fMRI studies. Psychiatry Research: Neuroimaging, 108:39-48. pdf
Maddock, RJ, Garrett, AS and Buonocore MH (2001). Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience, 104(3):667-76. pdf
Richard J. Maddock (2001). The lactic acid response to alkalosis in panic disorder: an integrative review. Journal of Neuropsychiatry and Clinical Neurosciences, 13(1):22-34. pdf
Maddock RJ. (1999). The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain. Trends in Neurosciences, 22:310-316. pdf