People - Michael Minzenberg

Michael Minzenberg, M.D.
Associate Professor of Clinical Psychiatry

M.D., McGill University Faculty of Medicine, 1995
M.S., Neurobiology, Rutgers University, 1988
B.S., Zoology, University of California, Davis, 1985

Research Interests
Dr. Minzenberg studies the neurochemical systems in the brain that modulate cognitive function in healthy individuals, and which may be related to cognitive dysfunction in persons with schizophrenia. These systems may serve as targets for novel medications to treat this illness. In addition, Dr. Minzenberg is interested in the processing of social and emotional information and its basis in cortico-limbic circuitry, and how dysfunction of this circuitry may relate to emotional and interpersonal disturbances in both schizophrenia and personality disorders.

Representative Publications

Minzenberg MJ, Watrous AJ, Yoon JH, Ursu S, Carter CS (2008). Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI. Science. 322(5908):1700-2. pdf

Minzenberg MJ, Fan J, New AS, Tang CY, Siever LJ (2008). Frontolimbic structural changes in borderline personality disorder. J Psychiatr Res. 42(9):727-33. pdf

Minzenberg MJ, Poole JH, Vinogradov S (2008). A neurocognitive model of borderline personality disorder: effects of childhood sexual abuse and relationship to adult social attachment disturbance. Dev Psychopathol. 20(1):341-68. pdf

Yoon JH, Minzenberg MJ, Ursu S, Ryan Walter BS, Wendelken C, Ragland JD, Carter CS (2008). Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral disorganization, and global function. Am J Psychiatry. 165(8):1006-14. pdf

Yoon JH, Tamir D, Minzenberg MJ, Ragland JD, Ursu S, Carter CS (2008). Multivariate pattern analysis of functional magnetic resonance imaging data reveals deficits in distributed representations in schizophrenia. Biol Psychiatry. 64(12):1035-41. pdf

Minzenberg MJ, Carter CS (2007). The quest for developing new treatments from imaging techniques: promises, problems and future potential. Expert Opin. Drug Discov. 2(9): 1-5. pdf

Minzenberg MJ, Carter CS (2007). Modafinil: A Review of Neurochemical Actions and Effects on Cognition. Neuropsychopharmacology. 1-26. pdf

Minzenberg MJ, Fan J, New AS, Tang CY, Siever LJ (2007). Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study. Psychiatry Res. 155(3):231-43. pdf

Hazlett EA, Speiser LJ, Goodman M, Roy M, Carrizal M, Wynn JK, Williams WC, Romero M, Minzenberg MJ, Siever LJ, New AS (2007). Exaggerated affect-modulated startle during unpleasant stimuli in borderline personality disorder. Biol Psychiatry. 62(3):250-5. pdf

Ragland JD, Yoon J, Minzenberg MJ, Carter CS (2007). Neuroimaging of cognitive disability in schizophrenia: search for a pathophysiological mechanism. Int Rev Psychiatry. 19(4):417-27. pdf

Minzenberg MJ, Xu K, Mitropoulou V, Harvey PD, Finch T, Flory JD, New AS, Goldman D, Siever LJ (2006). Catechol-O-methyltransferase genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder. Psychiatr Genet 16 (3):117-24. pdf

Minzenberg MJ, Poole JH, Vinogradov S (in press) Social-emotion recognition in borderline personality disorder. Comprehensive Psychiatry. pdf

Minzenberg MJ, Poole JH, Vinogradov S (2006). Adult social attachment disturbance is related to childhood maltreatment and current symptoms in borderline personality disorder. J Nerv Ment Dis 194 (5):341-8. pdf

Minzenberg MJ, Fisher-Irving M, Poole JH, Vinogradov S (2006). Reduced self-referential source memory performance is related to interpersonal dysfunction in borderline personality disorder. J Pers Disord 20 (1): 42-54. pdf

Minzenberg MJ, Grossman R, New AS, Mitropoulou V, Yehuda R, Goodman M, Reynolds D, Silverman J, Coccaro E, Marcus S, Siever LJ (2006). Blunted hormone responses to ipsapirone are associated with trait impulsivity in personality disorder patients. Neuropsychopharmacology 31(1):197-203. pdf

Hazlett EA, New AS, Newmark R, Haznedar MM, Lo JN, Speiser LJ, Chen AD, Mitropoulou V, Minzenberg M, Siever LJ, Buchsbaum MS (2005). Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biol Psychiatry 58(8):614-23. pdf

Minzenberg MJ, Poole JH, Benton C, Vinogradov S (2004). Association of anticholinergic load with impairment of complex attention and memory in schizophrenia. Am J Psychiatry 161(1):116-24. pdf

Minzenberg MJ, Poole JH, Shenaut GK, Ober BA, Vinogradov S (2003). Slowed access to semantic memory in schizophrenia is uniquely associated with positive and disorganized symptoms. Cogn Neuropsychiatry 8 (2): 107-127. pdf

Minzenberg MJ, Ober BA, Vinogradov S (2002). Semantic priming in schizophrenia: a review and synthesis. J Int Neuropsychol Soc 8(5): 699-720. pdf

Minzenberg M, Berkelaar M, Bray G, McKerracher L (1995). Changes in retinal ganglion cell axons after optic nerve crush: neurofilament expression is not the sole determinant of calibre. Biochem Cell Biol 73 (9-10): 599-604.

Auerbach SB, Minzenberg MJ, Wilkinson LO (1989). Extracellular serotonin and 5-hydroxyindoleacetic acid in hypothalamus of the unanesthetized rat measured by in vivo dialysis coupled to high-performance liquid chromatography with electrochemical detection: dialysate serotonin reflects neuronal release. Brain Res 499: 281-290. pdf

Yoon JH, Minzenberg MJ, Carter CS (in press). Brain function. In: G Thaker, WT Carpenter, eds. The Year in Schizophrenia, 2005. Clinical Publishing Ltd.

Minzenberg MJ, Siever LJ (2005). Biochemical Endophenotypes in Borderline Personality Disorder. In: MC Zanarini, ed. Borderline Personality Disorder. New York: Dekker.

Minzenberg MJ, Siever LJ (2005). Neurochemistry and Pharmacology of Psychopathy and Related Disorders. In: CJ Patrick, ed. Handbook of Psychopathy. New York: Guilford.

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